Anterior lenticonus & Alport Syndrome
Anterior lenticonus is an abnormality in the shape of the lens that affects about 15% to 20% of patients with X-linked and autosomal recessive Alport syndrome. People with anterior lenticonus may have a slow progressive deterioration of vision requiring patients to change the prescription of their glasses frequently. This condition may also lead to cataract formation.
Many people with Alport syndrome have abnormal pigmentation of the retina called dot-and-fleck retinopathy, but this does not result in any abnormalities of vision. This can be helpful diagnostically, though, especially in women who have no other features of Alport syndrome except hematuria (for which there are other causes).
Recurrent Corneal Erosion
Recurrent corneal erosion is another eye problem that can occur in people with Alport syndrome. Individuals who suffer from this have repeated episodes of eye pain, and may need to take measures to protect their corneas from minor trauma such as wearing goggles when riding a bicycle.
A macular hole is another eye issue that affects approximately 5% of patients. This results in a loss of vision and is an extension of the retinal thinning that occurs commonly in Alport syndrome. Affected individuals will complain of hazy or distorted vision.