Get A More Complete Picture With Renasight
Your Genes Have A Lot To Say
Natera’s Renasight is a test to determine if there is a genetic cause for your Alport syndrome, or to understand if you may be at increased risk for developing it due to your family history. Alport syndrome is often under- or mis-diagnosed and genetic testing is key to an early and accurate diagnosis.¹
Renasight is a non-invasive blood or saliva sample that tests 385 genes associated with chronic kidney disease (CKD) including those specific to Alport Syndrome.
Benefits from Genetic Testing
The more you and your physician know about the genetic cause of your kidney disease, the better prepared you’ll both be to make healthcare decisions for you and your family members.
Identify – the underlying cause of your kidney disease and, in some cases, slow the progression.²
Gain Insight – into personalized care options such as guidance on medication, early treatment, and referral to other specialists.
Educate – your family members on their potential risk, testing options, and possible benefits of earlier diagnosis.
Click here to download a patient brochure
How to Get Started
Request a test kit.
CLICK HERE to request a Renasight kit to be delivered to your home within 5-7 business days. Please note Renasight is unable to deliver to a PO Box.
Your provider submits an order.
Renasight requires a physician’s signature on the order form. Discuss with your physician if the test is right for you. You or your physician can call +1.650.425.4005 with any questions.
Provide a saliva sample.
The saliva sample is an easy cheek swab. Included in the kit are detailed collection instructions and a prepaid envelope to return the sample. If a blood sample is preferred, call +1.650.425.4005 and a complimentary at home mobile phlebotomy service can be scheduled at your convenience
Review your results with your provider.
Your Renasight results will be available in about 3 weeks to go over with your provider. Renasight offers a complimentary information session with a board-certified genetic counselor to answer any questions about your results.
FAQs:
Is genetic testing recommended for individuals with Alport syndrome?
A 2019 publication developed consensus guidelines on the use of genetic testing to diagnose Alport syndrome by an international group of expert physicians, geneticists and researchers.³
Can I talk to someone about Renasight prior to my physician ordering the test?
If you have questions about Renasight you can schedule a complimentary information session with one of our board certified genetic counselors
What if I need help understanding my Renasight results?
If after speaking with your physician and you still have questions regarding your results, with Renasight, you have access to a complimentary information session with a board-certified genetic counselor to review your results
What would my physician or I do with a positive result?
If you receive a positive Renasight result and have Alport syndrome, your doctor will work with you to see how these results may impact your treatment management. For example, earlier introduction of therapy may be effective in delaying time to dialysis and improving life expectancy.⁴
In addition, a positive result has implications for other biological or blood family members. Individuals typically have a genetic condition because it was inherited from their mother, father, or both parents. Importantly, there is an increased chance for your biological children or grandchildren to have the same genetic change as you, which may increase their risk to have kidney disease. For that reason, it is important to discuss your results with a certified genetic counselor to understand the chances for your family to have the same genetic condition.
Will my health insurance cover the cost of the Renasight test?
All insurance plans are welcome. Most patients have limited to no patient responsibility. To protect against unexpected costs, Natera will generate an insurance estimate and if we estimate your cost to exceed $349, we will contact you to discuss a discounted self-pay cash option as an alternative. Contact [email protected] or call +1.650.425.4005 to get a cost estimate.
Natera offers a Compassionate Care Program. Natera proactively verifies eligibility for this program. Eligible individuals will owe between $0-$149, based on federal income criteria and household size.
What happens if I have government insurance or no insurance at all?
For government insurance such as Medicare, Medicaid, and Tricare, Natera does not expect you to have any out-of-pocket expense.
Natera offers a Compassionate Care Program. Natera proactively verifies eligibility for this program. Eligible individuals will owe between $0-$149, based on federal income criteria and household size.
How can my family members get tested for Alport syndrome?
If you or a family member has received a positive genetic result you may have up to a 50% chance of having the same genetic mutation increasing your risk of developing Alport syndrome.
To learn more about the importance of family testing, click here.
References:
- https://www.alportsyndrome.org/about-alport-syndrome/top-5-things-for-medical-professionals
- https://pubmed.ncbi.nlm.nih.gov/26908832/
- Savige J., Ariani F., Mari F, et al. Expert consensus guidelines for the genetic diagnosis of Alport syndrome. Pediatr Nephrol. 2019;34(7):1175–1189
- Gross O., Licht C., Anders H.J, et al. Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney Int. 2012;81(5):494–501.
